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JAK/HDAC-IN-1

CAT: 0804-HY-126141-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126141-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].
CAS Number
2284621-75-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HDAC; JAK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Concentration
10mM
Purity
98.63
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1
Molecular Formula
C19H21Cl2N7O2
Molecular Weight
450.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62 (8) :3898-3923.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC; HDAC2; HDAC6; HDAC8; JAK1; JAK2; JAK3; Tyk2

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