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JAK kinase-IN-1

CAT:
804-HY-156535
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
JAK kinase-IN-1 - image 1

JAK kinase-IN-1

  • UNSPSC Description:

    JAK kinase-IN-1 (Example 1) is a JAK inhibitor. JAK kinase-IN-1 inhibits TYK2, JAK1, JAK2 and JAK3 with IC50 values of 4.2 nM, 32 nM, 27 nM, 3473 nM respectively[1].

  • Target Antigen:

    JAK

  • Type:

    Reference compound

  • Related Pathways:

    Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

  • Applications:

    COVID-19-immunoregulation

  • Field of Research:

    Inflammation/Immunology

  • Assay Protocol:

    https://www.medchemexpress.com/jak-kinase-in-1.html

  • Solubility:

    10 mM in DMSO

  • Smiles:

    O=C([C@H]1C(F)(F)C1)N([C@H](CS2)C3)[C@@H]2CN3C4=CC=NC(NC5=CN(C)N=C5)=N4

  • Molecular Weight:

    407.44

  • References & Citations:

    [1]Yao, Yuanshan, et al. Preparation of (pyrimidinyl)thiadiazabicyclo[3.2.1]octane derivatives as JAK kinase inhibitor and used for preventing and/or treating diseases or disorders related to JAK kinase activity or expression. Patent. WO2021180143.

  • Shipping Conditions:

    Room temperature

  • Clinical Information:

    No Development Reported

  • CAS Number:

    2698389-43-2

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Alternative Products

CAT

Name

MBS623273-01Hematopoietic Progenitor Kinase 1 (HPK1, Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAP4K1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1)
MBS6004364-01MAP4K1 (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
MBS628049-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
MBS624216-01MAP4K1, phosphorylated (Ser171) (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1)
MBS6488248-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (Biotin)
MBS6488236-01MAP4K1, Phosphorylated (Ser171) (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (APC)
MBS6488255-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (MaxLight 750)
MBS6488251-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (MaxLight 405)
MBS6488249-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (FITC)
MBS6488247-01MAP4K1, CT (Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, MAPK/ERK Kinase Kinase Kinase 1, MEK Kinase Kinase 1, MEKKK 1, Hematopoietic Progenitor Kinase, HPK1) (APC)