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Belvarafenib (TFA)

CAT: 0804-HY-109080ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109080ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].
CAS Number
2443966-84-3
Product Name Alternative
HM95573 (TFA) ; GDC-5573 (TFA) ; RG6185 (TFA)
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/belvarafenib-tfa.html
Purity
99.0
Solubility
10 mM in H2O
Smiles
O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O
Molecular Formula
C25H17ClF4N6O3S
Molecular Weight
592.95
References & Citations
[1]WO 2013/100632 A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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