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Belvarafenib

CAT: 0804-HY-109080-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109080-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].
CAS Number
1446113-23-0
Product Name Alternative
HM95573; GDC-5573; RG6185
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Belvarafenib.html
Purity
98.97
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C
Molecular Formula
C23H16ClFN6OS
Molecular Weight
478.93
Precautions
H302, H315, H319, H335
References & Citations
[1]WO 2013/100632 A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
B-Raf; C-Raf

Alternative Products

CatalogName
BA6528-5Belvarafenib

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