PD-159020

CAT: 0804-HY-101598Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101598Size:1 Each
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Description
PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.
CAS Number
[177904-00-6]
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/PD-159020.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1CC2=CC=C(OCO3)C3=C2)=C(C4=CC=C(OCO5)C5=C4)C6=C1C=C(OCC7=CC=CC=C7)C(OC)=C6)O
Molecular Formula
C32H25NO8
Molecular Weight
551.54
References & Citations
[1]Amy Mbunker, et al. 1,3-diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists. Bioorganic & Medicinal Chemistry Letters. Volume 6, Issue 9, 7 May 1996, Pages 1061-1066
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA; ETB

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