LY 178002

• Description:

  LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

• UNSPSC:

  12352005

• Target:

  COX; Lipoxygenase; Phospholipase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/LY_178002.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NCS/C1=C/C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

• Molecular Formula:

  C18H25NO2S

• Molecular Weight:

  319.46

• References & Citations:

  [1]Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27 (3-4) :300-2.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-LOX; COX; Phospholipase A

• CAS Number:

  [107889-32-7]