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LY 367265

CAT: 0804-HY-156807Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-156807Size:1 Each
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Description
LY 367265 is a 5-hydroxytryptamine transporter (SERT) inhibitor (IC₅₀ = 3.1 nM) and a 5-HT₂A receptor antagonist (Kᵢ = 0.81 nM) . LY 367265 has the inhibitory activity on the norepinephrine transporter (NET) of extremely weak (IC₅₀ > 1000 nM) ; it has low affinity for subtypes such as 5-HT₁B (Kᵢ = 490 nM) and 5-HT₁D (Kᵢ = 81 nM), showing high selectivity. LY 367265 concentration-dependently enhances of [³H]5-HT efflux (EC₅₀ = 250 nM) . LY 367265 antagonizes the contraction response of Sumatriptan (HY-B0121B), indicating its functional antagonistic activity on 5-HT₁D-like receptors. LY 367265 can be used for the study of diseases such as anxiety disorders and post-traumatic stress disorder[1].
CAS Number
[210751-39-6]
UNSPSC
12352005
Target
5-HT Receptor; Serotonin Transporter
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S1(N(CCN2CC=C(CC2)C3=CNC4=C3C=CC(F)=C4)C5=CC=CC6=C5N1CCC6)=O
Molecular Formula
C24H25FN4O2S
Molecular Weight
452.54
References & Citations
[1]Pullar IA, et al. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine (2A) receptor antagonist: a comparison with the antidepressant, nefazodone. Eur J Pharmacol. 2000 Oct 27;407 (1-2) :39-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor

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