LY-300168

CAT: 0804-HY-136844Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-136844Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY 300168 (GYKI 53655) is a non-competitive, blood-brain-barrier permeable AMPA receptor antagonist. LY 300168 attenuates hippocampal injury. LY 300168 blocks the sound-induced clonic and tonic convulsions[1][2].
CAS Number
[143692-18-6]
Product Name Alternative
GYKI 53655
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3CC1C)NC
Molecular Formula
C19H20N4O3
Molecular Weight
352.39
Precautions
P261-P280-P302+P352
References & Citations
[1]Liu XH, et al. The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents. Neurosci Lett. 1997 Oct 10;235 (1-2) :93-7. |[2]Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55 (3) :387-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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