PF-02575799

CAT: 0804-HY-100333Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100333Size:1 Each
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Description
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
CAS Number
[863491-70-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Microsomal Triglyceride Transfer Protein (MTP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MTP-IN-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2N=C(NC(C3=CC=CC=C3C4=CC=C(OC(C)C)C=C4)=O)C=CC2=C1)N[C@@H](C5=CC=CC=C5)C(N(CC6=CC=C(F)C=C6)C)=O
Molecular Formula
C42H37FN4O4
Molecular Weight
680.77
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Robinson RP, et al. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett. 2011 Jul 15;21 (14) :4150-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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