KW-8232 free base

• Description :

  KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor; SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/KW-8232_free_base.html

• Purity :

  95.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(N1CCN(C)C)=C(C(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3)C4=C1C=CC=C4)N5CCN(C6=CC=CC=C6Cl)CC5

• Molecular Formula :

  C36H37ClN4O3

• Molecular Weight :

  609.16

• References & Citations :

  [1]Uchii M, et al. Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats. Jpn J Pharmacol. 1998 Oct;78 (2) :241-3.|[2]Shiwei Wang, et al. A Transferable Deep Learning Approach to Fast Screen Potent Antiviral Drugs against SARS-CoV-2. bioRxiv. 2020.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EP

• CAS Number :

  [170365-25-0]