Products for Research Use Only
RegisterLogin

AR antagonist 5

CAT: 0804-HY-157455Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-157455Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC50 value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure[1.
CAS Number
2902679-53-0
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-5.html
Solubility
10 mM in DMSO
Smiles
C[C@](CN1CC2CC(N2C3=CC=C(C=C3)C#N)C1)(C(NC4=CN=C(C(C(F)(F)F)=C4)C#N)=O)O
Molecular Formula
C23H21F3N6O2
Molecular Weight
470.45
References & Citations
[1]Wenqiang Zhang, et al. Discovery of (2 S) - N- (6-Cyano-5- (trifluoromethyl) pyridin-3-yl) -3- (6- (4-cyanophenyl) -3,6-diazabicyclo[3.1.1]heptan-3-yl) -2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. J Med Chem. 2024, 67,1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-159922AR antagonist 9
HY-163363β-AR antagonist 2
HY-142923AR antagonist 2
HY-130845-01AR antagonist 1
HY-144127-01AR antagonist 3
HY-151266AR antagonist 4
HY-173559AR antagonist 12
HY-172624AR antagonist 14
HY-170951AR antagonist 10
HY-160680AR antagonist 6

Alternative Products

CatalogName
TBI2441-250MGPranlukast, Leukotriene CysLT1 antagonist; GPR17 antagonist
TBI2597-50MGMontelukast, Leukotriene CysLT1 antagonist; GPR17 antagonist
cyt-538-01chGH Antagonist
cyt-215-01oGH Antagonist
4031352.0500VIP Antagonist
H-8650.0005PDGF Antagonist
JLB39188-01Vasopressin antagonist
254641Antagonist G
T36127-01TNF-α Antagonist
sc-221406BCCR4 Antagonist

Popular Products