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MAP2K6 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1741Size: 1 Kit - Containing One 96 Well Plate & All Necessary ReagentsDry Ice: NoHazardous: No
CAT#:0519-EKC1741Size:1 Kit - Containing One 96 Well Plate & All Necessary Reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The MAP2K6 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MAP2K6 protein expression profile in cells. The kit can be used for measuring the relative amounts of MAP2K6 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MAP2K6.
Synonyms
Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6;2.7.12.2; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3; MAP2K6; MEK6, MKK6, PRKMK6, SKK3
Gene Name
MAP2K6
UniProt
P52564
Reactivity
Human, Mouse, Rat
Tissue Specificity
Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG- dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Molecular Weight
37492 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Dual specificity mitogen-activated protein kinase kinase 6
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Binds to microtubules.

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