MARK3 Colorimetric Cell-Based ELISA

• Description:

  The MARK3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MARK3 protein expression profile in cells. The kit can be used for measuring the relative amounts of MARK3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MARK3.

• Synonyms:

  MAP/microtubule affinity-regulating kinase 3;2.7.11.1; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78; MARK3; CTAK1, EMK2

• Gene Name:

  MARK3

• UniProt:

  P27448

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitous.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Serine/threonine-protein kinase (PubMed:23666762) . Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule- associated protein MAPT/TAU (PubMed:23666762) . Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613) . Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714) .

• Molecular Weight:

  84429 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  MAP/microtubule affinity-regulating kinase 3

• Subcellular Location:

  Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.