JIP2 Colorimetric Cell-Based ELISA

• Description:

  The JIP2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor JIP2 protein expression profile in cells. The kit can be used for measuring the relative amounts of JIP2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on JIP2.

• Synonyms:

  C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2; MAPK8IP2; IB2, JIP2, PRKM8IPL

• Gene Name:

  MAPK8IP2

• UniProt:

  Q13387

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) .

• Molecular Weight:

  87975 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  C-Jun-amino-terminal kinase-interacting protein 2

• Subcellular Location:

  Cytoplasm. Accumulates in cell surface projections.