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FES Colorimetric Cell-Based ELISA

CAT: 0519-EKC1670Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1670Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The FES Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FES protein expression profile in cells. The kit can be used for measuring the relative amounts of FES in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FES.
Synonyms
Tyrosine-protein kinase Fes/Fps;2.7.10.2; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes; FES; FPS
Gene Name
FES
UniProt
P07332
Reactivity
Human, Mouse
Tissue Specificity
Widely expressed. Detected in adult colon epithelium.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Acts down- stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Molecular Weight
93497 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein kinase Fes/Fps
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.

UniProtKB · P07332

Tyrosine-protein kinase Fes/Fps

FES_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07332
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FES
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.2
Processing
—
Secondary accessions
B2R6E6, B4DUD0, E9PC94, E9PC95, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingLipid-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCytoplasmCytoplasmic vesicleCytoskeletonGolgi apparatusMembrane

Domain

Coiled coilSH2 domain

Molecular function

KinaseTransferaseTyrosine-protein kinase

PTM

Phosphoprotein

Disease

Proto-oncogeneTumor suppressor

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