CKI-epsilon Colorimetric Cell-Based ELISA

• Description:

  The CKI-epsilon Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CKI-epsilon protein expression profile in cells. The kit can be used for measuring the relative amounts of CKI-epsilon in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CKI-epsilon.

• Synonyms:

  Casein kinase I isoform epsilon; CKI-epsilon; CKIe;2.7.11.1; CSNK1E

• Gene Name:

  CSNK1E

• UniProt:

  P49674

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

• Molecular Weight:

  47315 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Casein kinase I isoform epsilon

• Subcellular Location:

  Cytoplasm. Nucleus.