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MAEA Colorimetric Cell-Based ELISA

CAT: 0519-EKC1860Size: 1 Kit - Containing One 96 Well Plate & All Necessary ReagentsDry Ice: NoHazardous: No
CAT#:0519-EKC1860Size:1 Kit - Containing One 96 Well Plate & All Necessary Reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The MAEA Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MAEA protein expression profile in cells. The kit can be used for measuring the relative amounts of MAEA in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MAEA.
Synonyms
E3 ubiquitin-protein transferase MAEA;2.3.2.27 ; Cell proliferation-inducing gene 5 protein ; Erythroblast macrophage protein ; Human lung cancer oncogene 10 protein; HLC-10; Macrophage erythroblast attacher; P44EMLP ; MAEA; EMP ; HLC10, PIG5
Gene Name
MAEAEMP
UniProt
Q7L5Y9
Reactivity
Human, Mouse, Rat
Tissue Specificity
Detected at macrophage membranes (at protein level) .Ubiquitous.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972) . MAEA is required for normal cell proliferation (PubMed:29911972) . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972) . Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity) . Mediates the attachment of erythroid cell to mature macrophages; this MAEA- mediated contact inhibits erythroid cell apoptosis (PubMed:9763581) . Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity) . May contribute to nuclear architecture and cells division events (Probable) .
Molecular Weight
45287 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
E3 ubiquitin-protein transferase MAEA
Subcellular Location
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Detected in a nuclear, speckled-like pattern (PubMed:16510120) . Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120) . Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity) .

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