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ELL Colorimetric Cell-Based ELISA

CAT: 0519-EKC1753Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1753Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ELL Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ELL protein expression profile in cells. The kit can be used for measuring the relative amounts of ELL in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ELL.
Synonyms
RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein; ELL; C19orf17
Gene Name
ELL
UniProt
P55199
Reactivity
Human, Mouse
Tissue Specificity
Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780) . Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780) . ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Molecular Weight
68265 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
RNA polymerase II elongation factor ELL
Subcellular Location
Nucleus. Nucleus speckle. Nucleus, Cajal body. Colocalizes with EAF2 to nuclear speckles (PubMed:12446457) . Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606) . Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (PubMed:23932780) .

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