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STEA3 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1854Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1854Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The STEA3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor STEA3 protein expression profile in cells. The kit can be used for measuring the relative amounts of STEA3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on STEA3.
Synonyms
Metalloreductase STEAP3;1.16.1.-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde; STEAP3; TSAP6
Gene Name
STEAP3
UniProt
Q658P3
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) . Can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. Uses NADP (+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
Molecular Weight
54601 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Metalloreductase STEAP3
Subcellular Location
Endosome membrane; Multi-pass membrane protein. Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

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