Synuclein Colorimetric Cell-Based ELISA Kit

• Description:

  The Synuclein Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Synuclein protein expression profile in cells. The kit can be used for measuring the relative amounts of Synuclein in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Synuclein.

• Synonyms:

  Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP, PARK1

• Gene Name:

  SNCA

• UniProt:

  P37840

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

• Molecular Weight:

  14460 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Alpha-synuclein

• Subcellular Location:

  Cytoplasm, cytosol. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons.