Synuclein-alpha (Phospho-Tyr133) Colorimetric Cell-Based ELISA Kit

• Description:

  The Synuclein-alpha (Phospho-Tyr133) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Synuclein-alpha (Phospho-Tyr133) protein expression profile in cells. The kit can be used for measuring the relative amounts of Synuclein-alpha (Phospho-Tyr133) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Synuclein-alpha (Phospho-Tyr133) .

• Synonyms:

  Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP, PARK1

• Gene Name:

  SNCA

• UniProt:

  P37840

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

• Molecular Weight:

  14460 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Alpha-synuclein

• Subcellular Location:

  Cytoplasm, cytosol. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons.