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SENP1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1511Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1511Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The SENP1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SENP1 protein expression profile in cells. The kit can be used for measuring the relative amounts of SENP1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SENP1.
Synonyms
Sentrin-specific protease 1;3.4.22.-; Sentrin/SUMO-specific protease SENP1; SENP1
Gene Name
SENP1
UniProt
Q9P0U3
Reactivity
Human, Mouse
Tissue Specificity
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032) .
Molecular Weight
73481 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Sentrin-specific protease 1
Subcellular Location
Nucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.

UniProtKB · Q9P0U3

Sentrin-specific protease 1

SENP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9P0U3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SENP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.22.-
Processing
—
Secondary accessions
A8K7P5, Q86XC8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProteaseThiol protease

PTM

Phosphoprotein

Biological process

Ubl conjugation pathway

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