PDE4D Colorimetric Cell-Based ELISA Kit

• Description:

  The PDE4D Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PDE4D protein expression profile in cells. The kit can be used for measuring the relative amounts of PDE4D in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PDE4D.

• Synonyms:

  CAMP-specific 3',5'-cyclic phosphodiesterase 4D;3.1.4.53; DPDE3; PDE43; PDE4D; DPDE3

• Gene Name:

  PDE4D

• UniProt:

  Q08499

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in colonic epithelial cells (at protein level) . Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

• Molecular Weight:

  91115 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  CAMP-specific 3',5'-cyclic phosphodiesterase 4D

• Subcellular Location:

  Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity) . Colocalized with SHANK2 to the apical membrane of colonic crypt cells.