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PTP1B Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1489Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1489Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The PTP1B Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PTP1B protein expression profile in cells. The kit can be used for measuring the relative amounts of PTP1B in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PTP1B.
Synonyms
Tyrosine-protein phosphatase non-receptor type 1;3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; PTP1B
Gene Name
PTPN1
UniProt
P18031
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Molecular Weight
49967 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein phosphatase non-receptor type 1
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane.

UniProtKB · P18031

Tyrosine-protein phosphatase non-receptor type 1

PTN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18031
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
—
Secondary accessions
Q5TGD8, Q9BQV9, Q9NQQ4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationOxidationPhosphoproteinS-nitrosylation

Cellular component

Endoplasmic reticulumMembrane

Molecular function

HydrolaseProtein phosphatase

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