TOB1 Colorimetric Cell-Based ELISA Kit

• Description:

  The TOB1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TOB1 protein expression profile in cells. The kit can be used for measuring the relative amounts of TOB1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TOB1.

• Synonyms:

  Protein Tob1; Transducer of erbB-2 1; TOB1; TOB, TROB1

• Gene Name:

  TOB1

• UniProt:

  P50616

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitous.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473) . Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257) .

• Molecular Weight:

  38155 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Protein Tob1

• Subcellular Location:

  Cytoplasm. Nucleus. Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.