Nrf2 Colorimetric Cell-Based ELISA Kit

• Description:

  The Nrf2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Nrf2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Nrf2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Nrf2.

• Synonyms:

  Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2; NFE2L2; NRF2

• Gene Name:

  NFE2L2

• UniProt:

  Q16236

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

• Molecular Weight:

  67827 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Nuclear factor erythroid 2-related factor 2

• Subcellular Location:

  Cytoplasm, cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.