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MCM2 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1354Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1354Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The MCM2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MCM2 protein expression profile in cells. The kit can be used for measuring the relative amounts of MCM2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MCM2.
Synonyms
BM28; CDCL1; DNA replication licensing factor MCM2; KIAA0030; MCMD2; Nuclear protein BM28
Gene Name
MCM2
UniProt
P49736
Reactivity
Human, Mouse
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.
Molecular Weight
101896 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
DNA replication licensing factor MCM2
Subcellular Location
Nucleus.

UniProtKB · P49736

DNA replication licensing factor MCM2

MCM2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49736
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MCM2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.12
Processing
—
Secondary accessions
Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Biological process

Cell cycleDNA replication

Cellular component

ChromosomeNucleus

Disease

DeafnessDisease variantNon-syndromic deafness

Molecular function

DNA-bindingHelicaseHydrolase

Domain

Zinc-finger

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