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LAT Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1337Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1337Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The LAT Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor LAT protein expression profile in cells. The kit can be used for measuring the relative amounts of LAT in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on LAT.
Synonyms
36 kDa phospho-tyrosine adaptor protein; Linker for activation of T cells; p36-38; pp36
Gene Name
LAT
UniProt
O43561
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level) .
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Required for TCR (T-cell antigen receptor) - and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Molecular Weight
27930 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Linker for activation of T-cells family member 1
Subcellular Location
Cell membrane; Single-pass type III membrane protein. Present in lipid rafts.

UniProtKB · O43561

Linker for activation of T-cells family member 1

LAT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43561
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LAT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7WPI0, C7C5T6, G5E9K3, O43919
Protein keywords

Biological process

Adaptive immunityImmunityMast cell degranulation

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

Signal-anchorTransmembraneTransmembrane helix

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