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GSK3alpha/beta Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1254Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1254Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The GSK3alpha/beta Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GSK3alpha/beta protein expression profile in cells. The kit can be used for measuring the relative amounts of GSK3alpha/beta in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GSK3alpha/beta.
Synonyms
Factor A; GSK-3 alpha; GSK3-alpha; Glycogen synthase kinase-3 alpha; kinase GSK3-alpha
Gene Name
GSK3A
UniProt
P49840
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Molecular Weight
50981 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Glycogen synthase kinase-3 alpha

UniProtKB · P49840

Glycogen synthase kinase-3 alpha

GSK3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49840
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GSK3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GSK-3 alpha
EC number
2.7.11.26
Processing
—
Secondary accessions
O14959
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Disease

Alzheimer diseaseDiabetes mellitus

Ligand

ATP-bindingNucleotide-binding

Biological process

Carbohydrate metabolismGlycogen metabolismNeurogenesisWnt signaling pathway

Molecular function

KinaseSerine/threonine-protein kinaseSignal transduction inhibitorTransferase

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