ERAB Colorimetric Cell-Based ELISA Kit

• Description:

  The ERAB Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ERAB protein expression profile in cells. The kit can be used for measuring the relative amounts of ERAB in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ERAB.

• Synonyms:

  3-hydroxyacyl-CoA dehydrogenase type-2;3-hydroxyacyl-CoA dehydrogenase type II; Type II HADH;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;17-beta-hydroxysteroid dehydrogenase 10; Mitochondrial ribonuclease P protein 2; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Short-chain type dehydrogenase/reductase XH98G2; HSD17B10ERAB; HADH2; MRPP2; SCHAD; XH98G2

• Gene Name:

  HSD17B10

• UniProt:

  Q99714

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424) . Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424) . Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011) . Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011) . By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779) . Essential for structural and functional integrity of mitochondria (PubMed:20077426) .

• Molecular Weight:

  26923 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  3-hydroxyacyl-CoA dehydrogenase type-2

• Subcellular Location:

  Mitochondrion.