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Epo-R Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1197Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1197Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Epo-R Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Epo-R protein expression profile in cells. The kit can be used for measuring the relative amounts of Epo-R in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Epo-R.
Synonyms
EPO-R; EPOR; Erythropoietin receptor precursor
Gene Name
EPOR
UniProt
P19235
Reactivity
Human, Mouse, Rat
Tissue Specificity
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Molecular Weight
55065 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Erythropoietin receptor
Subcellular Location
Cell membrane; Single-pass type I membrane protein.

UniProtKB · P19235

Erythropoietin receptor

EPOR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19235
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPOR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
EPO-R
EC number
—
Processing
Precursor
Secondary accessions
B2RCG4, Q15443, Q2M205
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Congenital erythrocytosisDisease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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