Epo-R (Phospho-Tyr368) Colorimetric Cell-Based ELISA Kit

• Description:

  The Epo-R (Phospho-Tyr368) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Epo-R (Phospho-Tyr368) protein expression profile in cells. The kit can be used for measuring the relative amounts of Epo-R (Phospho-Tyr368) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Epo-R (Phospho-Tyr368) .

• Synonyms:

  EPO-R; EPOR; Erythropoietin receptor precursor

• Gene Name:

  EPOR

• UniProt:

  P19235

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

• Molecular Weight:

  55065 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Erythropoietin receptor

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.