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EPHA7 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1192Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1192Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The EPHA7 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EPHA7 protein expression profile in cells. The kit can be used for measuring the relative amounts of EPHA7 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EPHA7.
Synonyms
Ephrin type-A receptor 7; Tyrosine-protein kinase receptor EHK-3; EPH homology kinase 3; Receptor protein-tyrosine kinase HEK11; EHK3; HEK11
Gene Name
EPHA7
UniProt
Q15375
Reactivity
Human, Mouse, Rat
Tissue Specificity
Widely expressed.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase (CASP3) -dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Molecular Weight
112097 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Ephrin type-A receptor 7
Subcellular Location
Cell membrane; Single-pass type I membrane protein.

UniProtKB · Q15375

Ephrin type-A receptor 7

EPHA7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15375
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHA7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A0AUX7, B2R8W1, B7ZLJ9, B7ZLK0, Q59G40, Q5VTU0, Q8N368, Q9H124
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisNeurogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

GlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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