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ETK Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1204Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1204Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ETK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ETK protein expression profile in cells. The kit can be used for measuring the relative amounts of ETK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ETK.
Synonyms
BMX; BMX NON-receptor tyrosine kinase; Bone marrow kinase BMX; Cytoplasmic BMX; Epithelial and endothelial tyrosine kinase; NTK38; Protein tyrosine kinase BMX; kinase Etk
Gene Name
BMX
UniProt
P51813
Reactivity
Human, Mouse
Tissue Specificity
Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Molecular Weight
78011 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Cytoplasmic tyrosine-protein kinase BMX
Subcellular Location
Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1.

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