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EPHA5 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1191Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1191Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The EPHA5 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EPHA5 protein expression profile in cells. The kit can be used for measuring the relative amounts of EPHA5 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EPHA5.
Synonyms
EHK1; Eph homology kinase-1; Ephrin type-A receptor 5 precursor; HEK7; Receptor protein- tyrosine kinase HEK7; Tyrosine-protein kinase receptor EHK-1
Gene Name
EPHA5
UniProt
P54756
Reactivity
Human, Mouse, Rat
Tissue Specificity
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity) .
Molecular Weight
114803 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Ephrin type-A receptor 5
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

UniProtKB · P54756

Ephrin type-A receptor 5

EPHA5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54756
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHA5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q7Z3F2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionMembrane

PTM

GlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Biological process

Neurogenesis

Domain

RepeatSignalTransmembraneTransmembrane helix

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