CSE1L Colorimetric Cell-Based ELISA Kit

• Description:

  The CSE1L Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CSE1L protein expression profile in cells. The kit can be used for measuring the relative amounts of CSE1L in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CSE1L.

• Synonyms:

  CAS; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1-like; Exp2; exportin-2; importin-alpha re-exporter; XPO2

• Gene Name:

  CSE1L

• UniProt:

  P55060

• Reactivity:

  Human

• Tissue Specificity:

  Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944) . Widely expressed (PubMed:10331944) . Highly expressed in testis and in proliferating cells (PubMed:7479798, PubMed:10331944) .

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

• Molecular Weight:

  110417 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Exportin-2

• Subcellular Location:

  Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.