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EDD Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1179Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1179Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The EDD Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EDD protein expression profile in cells. The kit can be used for measuring the relative amounts of EDD in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EDD.
Synonyms
100 kDa protein; EDD; EDD1; hHYD; Hyperplastic discs protein homolog; KIAA0896; Progestin-induced protein; Ubiquitin--protein ligase EDD; UBR5
Gene Name
UBR5
UniProt
O95071
Reactivity
Human, Mouse
Tissue Specificity
Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity) . Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Molecular Weight
309352 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
E3 ubiquitin-protein ligase UBR5
Subcellular Location
Nucleus.

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