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Cox1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1136Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1136Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Cox1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Cox1 protein expression profile in cells. The kit can be used for measuring the relative amounts of Cox1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Cox1.
Synonyms
Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1; PTGS1; COX1
Gene Name
PTGS1
UniProt
P23219
Reactivity
Human
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Molecular Weight
68686 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Prostaglandin G/H synthase 1
Subcellular Location
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

UniProtKB · P23219

Prostaglandin G/H synthase 1

PGH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23219
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTGS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.99.1
Processing
Precursor
Secondary accessions
A8K1V7, B4DHQ2, B4E2S5, Q15122, Q3HY28, Q3HY29, Q5T7T6, Q5T7T7, Q5T7T8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

DioxygenaseOxidoreductasePeroxidase

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainSignal

Cellular component

Endoplasmic reticulumMembraneMicrosome

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolismProstaglandin biosynthesisProstaglandin metabolism

Ligand

HemeIronMetal-binding

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