Catenin-gamma Colorimetric Cell-Based ELISA Kit

• Description:

  The Catenin-gamma Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Catenin-gamma protein expression profile in cells. The kit can be used for measuring the relative amounts of Catenin-gamma in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Catenin-gamma.

• Synonyms:

  CTNNG; DP3; Desmoplakin III; JUP; Junction plakoglobin; PDGB; PKGB; PLAK; catenin, gamma; gamma-catenin; plakoglobin

• Gene Name:

  JUP

• UniProt:

  P14923

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity) .

• Molecular Weight:

  81745 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Junction plakoglobin

• Subcellular Location:

  Cell junction, adherens junction.Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.