PI3K/Akt/mTOR-IN-4

• UNSPSC Description:

  PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent PI3K/Akt/mTOR and tubulin polymerization inhibitor. PI3K/Akt/mTOR-IN-4 induce apoptosis and cell cycle arrest at G2/M phase. PI3K/Akt/mTOR-IN-4 decreases the expression of p-PI3K, p-Akt, and p-mTOR, β-tubulin[1].

• Target Antigen:

  Akt; Apoptosis; Microtubule/Tubulin; mTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3k-akt-mtor-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(OC)C(OC)=CC(C2=NC3=CC(N4CCN(C)CC4)=C(C#CC5=CC=CC=C5F)C=C3N2)=C1

• Molecular Weight:

  500.56

• References & Citations:

  [1]Li SS, et al. Design, synthesis, and biological evaluation of novel benzimidazole derivatives as anti-cervical cancer agents through PI3K/Akt/mTOR pathway and tubulin inhibition. Eur J Med Chem. 2024 Apr 16;271:116425.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported