PI3Kα/mTOR-IN-1

PI3Kα/mTOR-IN-1

• CAS Number: 1013098-90-2
• UNSPSC Description: PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.
• Target Antigen: mTOR; PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Pyrido[2,3-d]pyrimidin-7_8H_-one,_2-amino-8-cyclopentyl-4-methyl-6-_1H-pyrazol-4-yl_-.html
• Purity: 99.30
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(C2=CNN=C2)=CC3=C(C)N=C(N)N=C3N1C4CCCC4
• Molecular Weight: 310.35
• References & Citations: [1]Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5098-103.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported