PI3K/Akt/mTOR-IN-5

PI3K/Akt/mTOR-IN-5

• UNSPSC Description: PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 inhibits excessive proliferation of tumor cells through the PI3K/AKT/mTOR and STAT3/GPX4 pathways. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis[1].
• Target Antigen: Akt; Apoptosis; mTOR; PI3K; STAT
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-akt-mtor-in-5.html
• Smiles: O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@](/C=C/C=C(C)/C(NCCN3CCCCC3)=O)(C)O4)(CC2)C4=O)OC
• Molecular Weight: 542.66
• References & Citations: [1]Qian Xu, et al. "Design, synthesis, and in vivo and in vitro biological screening of pseudolaric acid B derivatives as potential anti-tumor agents." Bioorganic Chemistry (2024): 107670.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported