PI3K/AKT-IN-4

• UNSPSC Description:

  PI3K/AKT-IN-4 (compound 3) is a diterpenoid that can be isolated from the roots and rhizomes of Salvia castanea Dielsf. PI3K/AKT-IN-4 has antitumor activity, inhibiting cell viability and proliferation (IC50=4.72 μM) and promoting apoptosis by blocking the G0/G1 phase of the Hep3B cell cycle, inducing mitochondrial dysfunction and oxidative stress. In addition, PI3K/AKT-IN-4 inhibits hepatocellular carcinoma by inhibiting the PI3K-Akt signaling pathway and binding to PARP1 and CDK2 targets[1].

• Target Antigen:

  Akt; Apoptosis; CDK; PARP; PI3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3k-akt-in-4.html

• Smiles:

  OC1=CC2=C(C=C(C)C1=O)CC[C@@]3([H])C(C)(C)CCC[C@@]32C

• Molecular Weight:

  286.41

• References & Citations:

  [1]DongDong Wang, et al. "Identification of diterpenoids from Salvia castanea Diels f. tomentosa Stib and their antitumor activities." Bioorganic Chemistry (2024): 107701.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported