PI3K/Akt/mTOR-IN-3

PI3K/Akt/mTOR-IN-3

• CAS Number: 2457245-94-0
• UNSPSC Description: PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest[1].
• Target Antigen: Akt; Apoptosis; mTOR; PI3K
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-akt-mtor-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: CC1(C)C(C(C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(NCC=C)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C)=O
• Molecular Weight: 505.77
• References & Citations: [1]Wang SS, et al. Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway. Bioorg Chem. 2020 Aug;101:104036.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported