KU 59403

• Description:

  KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively[1].

• UNSPSC:

  12352005

• Target:

  ATM/ATR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/KU_59403.html

• Purity:

  99.23

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NC (C=C1S2) =CC=C1SC3=C2C=CC=C3C4=CC (C=C (N5CCOCC5) O4) =O) CCN6CCN (C) CC6

• Molecular Formula:

  C29H32N4O4S2

• Molecular Weight:

  564.72

• References & Citations:

  [1]Batey MA, et al. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Mol Cancer Ther. 2013 Jun;12 (6) :959-67.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  845932-30-1