KU-0058948

• Description:

  KU-0058948 is a specific and potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; PARP

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C1NN=C(CC2=CC=C(F)C(C(N3CCNCCC3)=O)=C2)C4=C1C=CC=C4

• Molecular Formula:

  C21H21FN4O2

• Molecular Weight:

  380.42

• References & Citations:

  [1]Gaymes TJ, et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica. 2009 May;94 (5) :638-46.|[2]Hannah Farmer, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005 Apr 14;434 (7035) :917-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  PARP1

• CAS Number:

  [763111-49-5]