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PSMA binder-2

CAT: 0804-HY-158125-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158125-01Size:5 mg
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Description
PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) [1][2].
CAS Number
2149567-00-8
UNSPSC
12352005
Target
PSMA
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/psma-binder-2.html
Purity
97.35
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C#CC1=CC=CC(NC(NCCCC[C@@H](C(OC(C)(C)C)=O)NC(N[C@H](C(OC(C)(C)C)=O)CCC(OC(C)(C)C)=O)=O)=O)=C1
Molecular Formula
C33H50N4O8
Molecular Weight
630.77
References & Citations
[1]Sun M, et al. Prostate-Specific Membrane Antigen (PSMA) -Targeted Radionuclide Therapies for Prostate Cancer. Curr Oncol Rep. 2021 Mar 29;23 (5) :59.|[2]Zitzmann-Kolbe S, et al., Preclinical evaluation of an actinium-225 labeled PSMA-targeting small molecule (225Ac-PSMA-Trillium (BAY 3563254) ) for the treatment of metastatic castration resistant prostate cancer (mCRPC) [J]. Cancer Research, 2024, 84 (6_Supplement) : 6033-6033.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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225287-01PSMA2 (HC3, Macropain Subunit C3, MU, multicatalytic endopeptidase Complex Subunit C3, PMSA2, Proteasome (prosome macropain) Subunit alpha Type 2, Proteasome alpha 2 Subunit, proteasome Component C3, proteasome Subunit alpha Type 2, Proteasome Subunit alpha Type-2, proteasome Subunit HC3, PSA2_HUMAN, PSC2, PSC3, PSMA 2, psmA2, ) discontinued
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046186-PEProstate Specific Membrane Antigen (PSMA, FGCP, Glutamate Carboxypeptidase 2, GCP2, Membrane Glutamate Carboxypeptidase, mGCP, N-acetylated alpha-linked Acidic Dipeptidase 1, NAALAD1, NAALADase I, NAALAdase, Pteroylpoly gamma Glutamate Carboxypeptidase) (PE)
MBS6254203-01Prostate Specific Membrane Antigen (PSMA, PSM, Folate Hydrolase, FOLH, FGCP, Glutamate Carboxypeptidase 2, GCP2, Membrane Glutamate Carboxypeptidase, mGCP, N-acetylated alpha-linked Acidic Dipeptidase 1, NAALAD1, NAALADase I, NAALAdase, Pteroylpoly gamma

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