RU 43044

CAT: 0804-HY-120016Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120016Size:1 Each
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Description
RU 43044 is a glucocorticoid receptor antagonist. RU 43044 shows an antidepressant-like effect, probably via an inhibition of enhanced prefrontal dopaminergic neurotransmission in these mouse models[1].
CAS Number
[136959-96-1]
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ru-43044.html
Smiles
O=C1CC[C@@]2(C3=CC[C@@]4([C@@](O)(CC[C@]4([C@@]3(CCC2=C1)[H])[H])C#CC)C)CC5=CC=C(C=C5)C
Molecular Formula
C29H34O2
Molecular Weight
414.58
References & Citations
[1]Ago Y, et al. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology. 2008 Dec;55 (8) :1355-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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