RU 43044

• Description :

  RU 43044 is a glucocorticoid receptor antagonist. RU 43044 shows an antidepressant-like effect, probably via an inhibition of enhanced prefrontal dopaminergic neurotransmission in these mouse models[1].

• UNSPSC :

  12352005

• Target :

  Glucocorticoid Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ru-43044.html

• Smiles :

  O=C1CC[C@@]2(C3=CC[C@@]4([C@@](O)(CC[C@]4([C@@]3(CCC2=C1)[H])[H])C#CC)C)CC5=CC=C(C=C5)C

• Molecular Formula :

  C29H34O2

• Molecular Weight :

  414.58

• References & Citations :

  [1]Ago Y, et al. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology. 2008 Dec;55 (8) :1355-63.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [136959-96-1]