RP-182

• Description:

  RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs) . RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research[1][2].

• UNSPSC:

  12352209

• Target:

  Apoptosis; Caspase; NF-κB; TNF Receptor

• Related Pathways:

  Apoptosis; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

• Molecular Formula:

  C69H103N19O11

• Molecular Weight:

  1374.68

• References & Citations:

  [1]Singh SS, et al. Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity. Mol Cancer Ther. 2024 Dec 3;23 (12) :1827-1841.|[2]Jaynes JM, et al. Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci Transl Med. 2020 Feb 12;12 (530) :eaax6337.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 8; NF-κB

• CAS Number:

  [1895883-60-9]