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Primordazine B

CAT: 0804-HY-125629Size: 1 EachDry Ice: NoHazardous: No
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Description
Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs) . Primordazine B inhibits a process called Poly (A) -tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT) . Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions[1].
CAS Number
339337-07-4
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/primordazine-b.html
Smiles
O=C(CSC1=NN=C2C(N(C3=C2C=CC=C3)CC)=N1)NCC4=CC=CO4
Molecular Formula
C18H17N5O2S
Molecular Weight
367.42
References & Citations
[1]Youngnam N Jin, et al. Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells[J]. Nature chemical biology, 2018, 14 (9) : 844-852.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

primordazine B
CAS Number339337-07-4
PubChem CID2857199
IUPAC Name2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide
Molecular FormulaC18H17N5O2S
Molecular Weight367.4
XLogP2.1
Topological Polar Surface Area111
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity496
SMILES
CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SCC(=O)NCC4=CC=CO4
InChI
InChI=1S/C18H17N5O2S/c1-2-23-14-8-4-3-7-13(14)16-17(23)20-18(22-21-16)26-11-15(24)19-10-12-6-5-9-25-12/h3-9H,2,10-11H2,1H3,(H,19,24)
InChIKey
JOMKYSCIYRKSMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of primordazine B
CAS: 339337-07-4
CID: 2857199
Formula: C18H17N5O2S
MW: 367.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass367.11029598
Monoisotopic Mass367.11029598
Topological Polar Surface Area111 Ų
Heavy Atom Count26
Formal Charge0
Complexity496
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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